GTX52639
NNT1 antibody [11D28]
Cannot supply to this region.
- SKU:
- GTX52639
- Additional Names:
- BSF3 , CISS2 , CLC , CLCF1 , NNT1 , NR6 , cardiotrophinlike cytokine factor 1 , cardiotrophin like cytokine factor 1
- Application:
- WB
- Concentration:
- 500 ug/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Human recombinant CLC
- Clone:
- 11D28
- Uniprot:
- Q9UBD9
- Synonyms:
- B-cell stimulatory factor 3;B-cell-stimulating factor 3;BSF-3;BSF3;cardiotrophin-like cytokine factor 1;CISS2;CLC;CRLF1 associated cytokine-like factor 1;neurotrophin-1/B-cell stimulating factor-3;NNT-1;NNT1;novel neurotrophin-1;NR6
- Extra Details:
- This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
- Shipping Conditions:
- Blue Ice