GTX50620
SHC1 antibody
Cannot supply to this region.
- SKU:
- GTX50620
- Additional Names:
- SHC adaptor protein 1 , SHC , SHCA
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Peptide sequence around aa.347~351 (H-Q-Y-Y-N) derived from human SHC1.
- Uniprot:
- P29353
- Synonyms:
- SH2 domain protein C1;SHC;SHC (Src homology 2 domain containing) transforming protein 1;SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;SHCA;Src homology 2 domain-containing-transforming protein C1
- Extra Details:
- This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Shipping Conditions:
- Blue Ice