GTX50242
Bcr (phospho Tyr177) antibody
Cannot supply to this region.
- SKU:
- GTX50242
- Additional Names:
- BCR activator of RhoGEF and GTPase , ALL , BCR1 , CML , D22S11 , D22S662 , PHL
- Application:
- WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Peptide sequence around phosphorylation site of tyrosine 177 (P-F-Y(p)-V-N) derived from human Bcr.
- Uniprot:
- P11274
- Synonyms:
- ALL;BCR, RhoGEF and GTPase activating protein;BCR/FGFR1 chimera protein;BCR1;breakpoint cluster region;breakpoint cluster region protein;CML;D22S11;D22S662;FGFR1/BCR chimera protein;PHL;renal carcinoma antigen NY-REN-26
- Extra Details:
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice