![BRCC36 antibody [AT3B1]](https://www.genetex.com/upload/website/prouct_img/normal/GTX50015/BRCC36-antibody-AT3B1_Western-blot_GTX50015-1_w_23060823_114.webp)
GTX50015
BRCC36 antibody [AT3B1]
Cannot supply to this region.
- SKU:
- GTX50015
- Additional Names:
- BRCA1/BRCA2-containing complex subunit 3 , BRCC36 , C6.1A , CXorf53
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS, 0.1% Sodium azide.
- Immunogen:
- Recombinant BRCC36 (1-316aa) purified from E. coli
- Clone:
- AT3B1
- Uniprot:
- P46736
- Synonyms:
- BRCA1-A complex subunit BRCC36;BRCA1/BRCA2-containing complex subunit 3;BRCA1/BRCA2-containing complex subunit 36;BRCC36;BRISC complex subunit BRCC36;C6.1A;CXorf53;lys-63-specific deubiquitinase BRCC36
- Extra Details:
- This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
- Shipping Conditions:
- Blue Ice