GTX48861
ThPok antibody
Cannot supply to this region.
- SKU:
- GTX48861
- Additional Names:
- zinc finger and BTB domain containing 7B , Thpok , Zfp67 , c-Krox
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 85 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human, Mouse
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Synthetic peptide corresponding to an internal sequence of mouse cKrox protein.
- Uniprot:
- Q64321
- Synonyms:
- c-Kr;c-Krox;krueppel-related zinc finger protein cKrox;T-helper-inducing POZ/Krueppel-like factor;Thp;Thpok;Vzinc finger and BTB domain containing 7B;Zfp6;Zfp67;zinc finger and BTB domain-containing protein 7B;zinc finger protein 67;zinc finger protein Th-POK
- Extra Details:
- cKrox (also known as Zfp67 or ThPOK) functions as a transcription regulator that acts as a key modulator of lineage commitment for immature T-cell precursors. cKrox is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. cKrox is a known transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes. cKrox is located within the nucleus and is expressed in multiple tissues and organs including skin, thymus and peripheral T-cells.
- Shipping Conditions:
- Blue Ice