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GTX48775
AHA-1 antibody [25F2.D9]
Cannot supply to this region.
- SKU:
- GTX48775
- Additional Names:
- AHA1, activator of heat shock protein ATPase 1 , BC023857 , p38
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human, Mouse
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rat
- Reactivities:
- Human
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, no preservatives.
- Immunogen:
- Full length recombinant mouse AHA1 protein followed by hybridoma development.
- Clone:
- 25F2.D9
- Uniprot:
- Q8BK64
- Synonyms:
- activator of 90 kDa heat shock protein ATPase homolog 1;Ah;AHA1, activator of heat shock 90kDa protein ATPase homolog 1;AHA1, activator of heat shock protein ATPase homolog 1;BC023857;p3;p38
- Extra Details:
- Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist client-protein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370-390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis.
- Shipping Conditions:
- Blue Ice