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GTX48646
MTBP antibody [PHL-1]
Cannot supply to this region.
- SKU:
- GTX48646
- Additional Names:
- MDM2 binding protein , MDM2BP
- Application:
- ELISA, WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Recombinant amino-terminal His 6X-tagged polypeptide corresponding to amino acid residues 667-812 of human MTBP protein.
- Clone:
- PHL-1
- Uniprot:
- Q96DY7
- Synonyms:
- MDM2 (mouse double minute 2)-binding protein, 104kD;mdm2-binding protein;Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa;MDM2BP
- Extra Details:
- The MDM2 onco-protein is over expressed in human cancer cells and it promotes tumorigenesis by directly blocking the function of the p53 tumor suppressor. Studies also indicate that MDM2 regulates cell prolifer-ation via p53 independent mechanisms. MTBP (Mdm2 [Two] Binding Protein) was identified by a yeast two-hybrid screen as an MDM2 binding protein (1). MTBP has been reported to modulate cell cycle progression by a p53 independent mechanism and suppress MDM2-mediated p53 degradation when ectopically expressed in cells (1,2). The human MTBP gene localizes to 8q24 (3) and MTBP RNA is expressed in a wide range of tissues, with highest being in the thymus, testes and ovaries (1).
- Shipping Conditions:
- Blue Ice