GTX48549
PLK1 antibody
Cannot supply to this region.
- SKU:
- GTX48549
- Additional Names:
- polo like kinase 1 , PLK , STPK13
- Application:
- WB, IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Unpurified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Bovine, Canine, Fish, Human, Mouse, Porcine, Rat
- Buffer:
- Serum diluted with PBS, 0.05% BSA, 0.05% Sodium azide.
- Immunogen:
- A portion of amino acids 100-200 of human PLK1 was used as the immunogen.
- Uniprot:
- P53350
- Synonyms:
- cell cycle regulated protein kinase;PLK;PLK-1;polo (Drosophia)-like kinase;Polo-like kinase 1;serine/threonine-protein kinase 13;serine/threonine-protein kinase PLK1;STPK13
- Extra Details:
- Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
- Shipping Conditions:
- Blue Ice