GTX47228
UPF3B antibody, Internal
Cannot supply to this region.
- SKU:
- GTX47228
- Additional Names:
- UPF3B regulator of nonsense mediated mRNA decay , HUPF3B , MRX62 , MRXS14 , RENT3B , UPF3BP1 , UPF3BP2 , UPF3BP3 , UPF3X , Upf3p-X
- Application:
- WB
- Concentration:
- 0.5-1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 2% Sucrose, 0.09% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to an Internal region of Human UPF3B
- Uniprot:
- Q9BZI7
- Synonyms:
- HUPF3B;mental retardation, X-linked 62;MRX62;MRX82;MRXS14;nonfunctional UPF3B regulator of nonsense mediated mRNA decay;nonsense mRNA reducing factor 3B;regulator of nonsense transcripts 3B;RENT3B;up-frameshift suppressor 3 homolog B;up-frameshift suppressor 3 homolog on chromosome X;UPF3 regulator of nonsense transcripts homolog B;UPF3B pseudogene 1;UPF3B pseudogene 2;UPF3B pseudogene 3;UPF3BP1;UPF3BP2;UPF3BP3;Upf3p-X;UPF3X
- Extra Details:
- This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice