SUN2 antibody, N-term

Cannot supply to this region.

SKU:: GTX46358
Additional Names:: Sad1 and UNC84 domain containing 2 , UNC84B
Application:: WB
Concentration:: 0.5-1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 2% Sucrose, 0.09% Sodium azide.
Immunogen:: A synthetic peptide corresponding to a N-terminal region of Human SUN2.
Uniprot:: Q9UH99
Synonyms:: nuclear envelope protein;protein unc-84 homolog B;rab5-interacting protein;rab5IP;Sad1 unc-84 domain protein 2;sad1/unc-84 protein-like 2;SUN domain-containing protein 2;unc-84 homolog B;UNC84B
Extra Details:: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]