GTX45517
HFE2 antibody, N-term
Cannot supply to this region.
- SKU:
- GTX45517
- Additional Names:
- hemojuvelin BMP co-receptor , HFE2 , HFE2A , JH , RGMC
- Application:
- WB
- Concentration:
- 0.5-1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 2% Sucrose, 0.09% Sodium azide.
- Immunogen:
- A synthetic peptide corresponding to a N-terminal region of Human HFE2
- Uniprot:
- Q6ZVN8
- Synonyms:
- haemojuvelin;hemochromatosis type 2 (juvenile);hemochromatosis type 2 protein;hemojuvelin;hemojuvelin BMP coreceptor;HFE2;HFE2A;JH;repulsive guidance molecule c;RGM domain family member C;RGMC
- Extra Details:
- The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
- Shipping Conditions:
- Blue Ice