GTX45097
DAP12 antibody
Cannot supply to this region.
- SKU:
- GTX45097
- Additional Names:
- TYRO protein tyrosine kinase binding protein , DAP12 , KARAP , PLOSL , PLOSL1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 0.1% Sodium azide.
- Immunogen:
- Recombinant protein - amino acids 28-40 of human DAP12.
- Uniprot:
- O43914
- Synonyms:
- DAP12;DNAX adaptor protein 12;DNAX-activation protein 12;KAR-associated protein;KARAP;killer-activating receptor-associated protein;PLOSL;PLOSL1;polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy;TYRO protein tyrosine kinase binding protein;TYRO protein tyrosine kinase-binding protein
- Extra Details:
- This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
- Shipping Conditions:
- Blue Ice