GTX41968
NKCC2 antibody
Cannot supply to this region.
- SKU:
- GTX41968
- Additional Names:
- Solute Carrier Family 12 Member 1 , Bsc1 , Nkcc2 , Slc12A1
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human, Rat
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Rabbit immunoglobulin, 50% Glycerol, no preservatives.
- Immunogen:
- AA109 to 129 of the rat sequence
- Synonyms:
- BSC1;bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1;bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2;kidney-specific Na-K-Cl symporter;Nkcc2;solute carrier family 12 (sodium/potassium/chloride transporter), member 1;solute carrier family 12 (sodium/potassium/chloride transporters), member 1;solute carrier family 12 member 1;Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
- Extra Details:
- NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide.
- Shipping Conditions:
- Blue Ice