Thymidylate synthase antibody [SPM453]

Cannot supply to this region.

SKU:: GTX35113
Additional Names:: HST422 , TMS , TS , TYMS , thymidylate synthetase , Thymidylate Synthase
Application:: Flow Cytometry, IHC-P, IF, ICC
Concentration:: 0.2 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: protein a/g purified
Storage Conditions:: 2-8[o]C
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 0.05% BSA, 0.05% Sodium azide.
Immunogen:: Recombinant full-length human TYMS protein.
Clone:: SPM453
Uniprot:: P04818
Synonyms:: HST422;thymidylate synthase;TMS;TS;TSase
Extra Details:: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]