GTX32488
CARD8 antibody
Cannot supply to this region.
- SKU:
- GTX32488
- Additional Names:
- caspase recruitment domain family member 8 , CARDINAL , DACAR , DAKAR , NDPP , NDPP1 , TUCAN
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8 (NP_003796.1).
- Uniprot:
- Q9Y2G2
- Synonyms:
- apoptotic protein NDPP1;CARD inhibitor of NF-kappaB-activating ligands;CARD-inhibitor of NF-kappa-B-activating ligand;CARDINAL;caspase recruitment domain-containing protein 8;DACAR;DAKAR;NDPP;NDPP1;TUCAN;tumor up-regulated CARD-containing antagonist of CASP9;tumor up-regulated CARD-containing antagonist of caspase nine
- Extra Details:
- The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
- Shipping Conditions:
- Blue Ice