GTX32001-PEP
PION blocking peptide
Cannot supply to this region.
- SKU:
- GTX32001-PEP
- Additional Names:
- Gamma-Secretase Activating Protein , Pion , Gsap
- Application:
- Neutralisation
- Concentration:
- 200 ug/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- gamma-secretase activating protein
- Species:
- Human
- Synonyms:
- gamma-secretase-activating protein;pigeon homolog;PION;protein pigeon homolog
- Extra Details:
- Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
- Shipping Conditions:
- Dry Ice