GTX31637
ASK1 antibody
Cannot supply to this region.
- SKU:
- GTX31637
- Additional Names:
- mitogen-activated protein kinase kinase kinase 5 , ASK1 , MAPKKK5 , MEKK5
- Application:
- ELISA, WB, IF, ICC
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Ion Exchange
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- ASK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human ASK1.The sequence is different from that of mouse by last two amino acids.The immunogen is located within the last 50 amino acids of ASK1.
- Uniprot:
- Q99683
- Synonyms:
- apoptosis signal-regulating kinase 1;ASK-1;ASK1;MAP/ERK kinase kinase 5;MAPK/ERK kinase kinase 5;MAPKKK5;MEK kinase 5;MEKK 5;MEKK5;mitogen-activated protein kinase kinase kinase 5
- Extra Details:
- Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice