GTX31604-PEP
Wip1 blocking peptide
Cannot supply to this region.
- SKU:
- GTX31604-PEP
- Additional Names:
- Protein Phosphatase, Mg2+/Mn2+ Dependent 1D , Iddgip , Pp2C-Delta , Wip1 , Ppm1D
- Application:
- Neutralisation
- Concentration:
- 200 ug/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- protein phosphatase, Mg2+/Mn2+ dependent 1D
- Species:
- Human
- Synonyms:
- IDDGIP;JDVS;PP2C-DELTA;protein phosphatase 1D;protein phosphatase Wip1;wild-type p53-induced phosphatase 1;WIP1
- Extra Details:
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Dry Ice