GTX31304
MDA5 antibody
Cannot supply to this region.
- SKU:
- GTX31304
- Additional Names:
- interferon induced with helicase C domain 1 , AGS7 , Hlcd , IDDM19 , MDA-5 , MDA5 , RLR-2 , SGMRT1
- Application:
- ELISA, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- MDA5 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human MDA5.The immunogen is located within the last 50 amino acids of MDA5.
- Uniprot:
- Q9BYX4
- Synonyms:
- AGS7;CADM-140 autoantigen;clinically amyopathic dermatomyositis autoantigen 140 kDa;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;helicard;helicase with 2 CARD domains;Hlcd;IDDM19;interferon-induced helicase C domain-containing protein 1;Interferon-induced with helicase C domain protein 1;MDA-5;MDA5;melanoma differentiation-associated gene 5;melanoma differentiation-associated protein 5;murabutide down-regulated protein;RIG-I-like receptor 2;RLR-2;RNA helicase-DEAD box protein 116;SGMRT1
- Extra Details:
- DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]
- Shipping Conditions:
- Blue Ice