PUMA antibody

Cannot supply to this region.

SKU:: GTX29643
Additional Names:: BBC3 , BCL2 binding component 3 , JFY1 , PUMA
Application:: ELISA, WB, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: Synthetic peptide corresponding to aa 180-193 of human PUMA-A Alpha (accession no NP_055232). This sequence is identical in human PUMA-A Alpha and PUMA-B Beta.
Uniprot:: Q96PG8, Q9BXH1
Synonyms:: bcl-2-binding component 3;JFY-1;JFY1;p53 up-regulated modulator of apoptosis;p53-upregulated modulator of apoptosis;PUMA
Extra Details:: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]