GTX29041
AKT peptide
Cannot supply to this region.
- SKU:
- GTX29041
- Additional Names:
- AKT 1
- Application:
- Neutralisation
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Genetex
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium Azide.
- Species:
- Human
- Extra Details:
- Akt (Protein Kinase B, PKB) is a key regulator of many signal transduction pathways (reviewed in ref 1). Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. Akt mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits Akt to the membrane, where it is activated by PDK1 phosphorylation (reviewed in 2). Once phosphorylated, Akt dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. Akt has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.
- Shipping Conditions:
- Dry Ice