GTX28395
TMS1 peptide
Cannot supply to this region.
- SKU:
- GTX28395
- Additional Names:
- Pyd And Card Domain Containing , Asc , Card5 , Tms , Tms-1 , Tms1 , Pycard
- Application:
- Neutralisation
- Concentration:
- 0.20 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Immunogen:
- PYD and CARD domain containing
- Species:
- Human
- Synonyms:
- apoptosis-associated speck-like protein containing a CARD;ASC;CARD5;caspase recruitment domain-containing protein 5;target of methylation-induced silencing 1;TMS;TMS-1;TMS1
- Extra Details:
- ASC (apoptosis-associated speck-like protein containing a CARD) or TMS 1 (target of methylation-induced silencing) is a recently identified CpG island-associated gene that becomes hypermethylated and silenced in cells overexpressing DNA cytosine-5-methyltransferase-1. TMS1 is aberrantly methylated and silenced in human breast cancer cells. Forty percent (11 of 27) of primary breast tumors exhibited aberrant methylation of ASC. Ectopic expression of ASC induced apoptosis in 293 cells and inhibited the survival of human breast cancer cells. The methylation-mediated silencing of ASC may confer a survival advantage by allowing cells to escape from apoptosis, supporting a new role for aberrant methylation in breast tumorigenesis. ASC encodes a 22-kDa predicted protein containing a COOH-terminal caspase recruitment domain (CARD). However, it is structurally unrelated to other known CARD adaptor and regulatory proteins. Ectopic expression of ASC alone was able to trigger apoptosis in 293 cells, and cell death correlated with relocalization of ASC from the cytoplasm to perinuclear, ball-like structures. Several lines of evidence support the idea that redistribution of ASC is an intermediate step in a ASC-triggered apoptotic pathway.
- Shipping Conditions:
- Dry Ice