BACE2 peptide

Cannot supply to this region.

SKU:: GTX28392
Additional Names:: Beta-Secretase 2 , Aeplc , Alp56 , Asp1 , Asp21 , Bae2 , Cda13 , Ceap1 , Drap , Bace2
Application:: Neutralisation
Concentration:: 0.20 mg/ml
Physical State:: Liquid
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Genetex
Buffer:: PBS, 0.1% BSA, 0.02% Sodium azide.
Immunogen:: beta-site APP-cleaving enzyme 2
Species:: Human
Synonyms:: 56 kDa aspartic-like protease;AEPLC;ALP56;ASP1;ASP21;aspartyl protease 1;BAE2;beta-secretase 2;beta-site amyloid beta A4 precursor protein-cleaving enzyme 2;beta-site APP-cleaving enzyme 2;CDA13;CEAP1;Down syndrome region aspartic protease;DRAP;memapsin-1;membrane-associated aspartic protease 1;SLCO3A1/BACE2 fusion;theta-secretase;transmembrane aspartic proteinase Asp1
Extra Details:: Accumulation of the abeta in plaques in the cerebral cortex is a critical event in the pathogenesis of Alzheimers disease. Abeta peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at by secretases. BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Ab. BACE2 locates on chromosome 21q22.3, the so-called Down critical region, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome.