Survivin peptide

Cannot supply to this region.

SKU:: GTX28122
Additional Names:: Baculoviral Iap Repeat-Containing 5 , Aac-11 , Api4 , Tiap , Survivin40 , Birc5
Application:: Neutralisation
Concentration:: 0.20 mg/ml
Physical State:: Liquid
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Genetex
Buffer:: PBS, 0.1% BSA, 0.02% Sodium azide.
Immunogen:: baculoviral IAP repeat-containing 5
Species:: Mouse
Synonyms:: A;AAC-11;Api4;apoptosis inhibitor 4;apoptosis inhibitor survivin;baculoviral IAP repeat-containing protein 5;s;survivin;survivin40;T;TIAP
Extra Details:: Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2 / M phase of the cell cycle in a cycle regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin microtubule interactions results in loss of survivin's anti apoptosis function and increased caspase 3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2 / M phase. The over expression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.