NFkB p50 peptide

Cannot supply to this region.

SKU:: GTX27550
Additional Names:: Nuclear Factor Kappa B Subunit 1 , Cvid12 , Ebp-1 , Kbf1 , Nf-Kb1 , Nf-Kappa-B1 , Nf-Kappab , Nfkb-P105 , Nfkb-P50 , Nfkappab , P105 , P50 , Nfkb1
Application:: Neutralisation
Physical State:: Liquid
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles.
Supplier:: Genetex
Buffer:: Serum, 0.01% Sodium azide.
Immunogen:: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Species:: Human
Synonyms:: CVID12;DNA-binding factor KBF1;EBP-1;KBF1;NF-kappa-B1;NF-kappaB;NF-kappabeta;NF-kB;NF-kB1;NFkappaB;NFKB-p105;NFKB-p50;nuclear factor kappa-B DNA binding subunit;nuclear factor NF-kappa-B p105 subunit;nuclear factor NF-kappa-B p50 subunit;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Extra Details:: NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. NF-kB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino-terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy-terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL-1alpha and TNF-alpha as mediated by IkB kinase and p38 MAPK. Serine 529 is located in a negatively charged region (amino acids 422-540) that is phosphorylated in response to phorbol myristate acetate plus calcium ionophore activation. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NF-kB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NF-kB has been associated with a number of inflammatory diseases while persistent inhibition of NF-kB leads to inappropriate immune cell development or delayed cell growth.

Shipping Conditions:: Dry Ice