beta Catenin antibody [6F9]

Cannot supply to this region.

SKU:: GTX26300
Additional Names:: catenin beta 1 , CHBCAT
Application:: WB, IHC-Fr, IF, ICC
Physical State:: Liquid
Species Reactivity:: Avian
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Bovine, Canine, Human, Mouse
Buffer:: Ascites, 15mM Sodium azide.
Immunogen:: recombinant chicken B Beta-catenin.
Clone:: 6F9
Synonyms:: beta catenin;catenin (cadherin-associated protein), beta 1, 88kDa;catenin beta-1;CHBCAT
Extra Details:: The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 protooncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Shipping Conditions:: Blue Ice