GTX26234
Livin peptide
Cannot supply to this region.
- SKU:
- GTX26234
- Additional Names:
- Baculoviral Iap Repeat Containing 7 , Kiap , Livin , Ml-Iap , Mliap , Rnf50 , Birc7
- Application:
- Neutralisation
- Concentration:
- 0.20 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Genetex
- Buffer:
- PBS, 0.1% BSA, 0.02% Sodium azide.
- Species:
- Human
- Synonyms:
- baculoviral IAP repeat-containing protein 7;KIAP;kidney inhibitor of apoptosis protein;LIVIN;livin inhibitor of apoptosis;melanoma inhibitor of apoptosis protein;ML-IAP;MLIAP;RING finger protein 50;RING-type E3 ubiquitin transferase BIRC7;RNF50
- Extra Details:
- Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin / XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP 3 and DR6. Livin has direct interaction with several caspases including caspase 3, 7, and 9. Livin inhibits the activation of caspase 9 induced by Apaf 1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
- Shipping Conditions:
- Dry Ice