PDGF Receptor alpha + beta (phospho Tyr572/Tyr574) antibody

Cannot supply to this region.

SKU:: GTX25443
Application:: WB, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, 0.1% BSA, 50% Glycerol, 0.05% Sodium azide.
Immunogen:: The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PDGFRa that contains tyrosines 572 and 574 and PDGFRa tyrosines 579 and 581. The sequence is conserved in PDGFRa mouse, rat and frog.
Extra Details:: Platelet-derived growth factor receptor (PDGFR) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo- or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF-AA, -BB or -AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation. PDGFR alpha tyrosines 572 and 574 (579 and 581 in PDGFR beta) are autophosphorylated in the activated receptor, and bind and activate Src family kinases.