GTX23455
Adiponectin antibody
Cannot supply to this region.
- SKU:
- GTX23455
- Additional Names:
- adiponectin, C1Q and collagen domain containing , 30kDa , APN , Acdc , Acrp30 , Ad , Adid , GBP28 , adipo , apM1
- Application:
- IHC, WB, IHC-P, IF, ICC, IP
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human, Mouse
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 0.1% BSA, 0.05% Sodium azide.
- Immunogen:
- Synthetic peptides corresponding to the residues E(18) D D V T T T E E L A P A L V(32) and F(187) T Y D Q Y Q E K N V D Q A(200) of mouse Adiponectin.
- Uniprot:
- Q60994
- Synonyms:
- 30 kDa adipocyte complement-related protein;30kDa;a;Acd;Acdc;Acr;Acrp30;Ad;Adid;adip;adipo;adipocyte complement related protein;adipocyte complement-related 30 kDa protein;adipocyte-specific protein AdipoQ;adipocyte, C1Q and collagen domain containing;adipocyte, C1q and collagen domain-containing protein;adiponectin;adiponectin d;ap;apM1;APN;GBP2;GBP28
- Extra Details:
- Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin and adiponectin protein of 30 kDa. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, mRNA levels of Adiponectin have been shown to be induced over 100-fold. Studies indicate that Adiponectin enhances the ability of sub-physiological levels of insulin to suppress glucose production, thus linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol-3-kinase (PI3-K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. mRNA levels of Adiponectin have been shown to be significantly reduced in adipose tissue of obese patients with Type 2 diabetes relative to control subjects. Structural similarities to TNFalpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Because Adiponectin is down-regulated in various forms of obesity and its structural similarity to TNFalpha, it is currently being investigated as an important regulator of whole body energy homeostasis.
- Shipping Conditions:
- Blue Ice