GTX23422
PREB antibody
Cannot supply to this region.
- SKU:
- GTX23422
- Additional Names:
- prolactin regulatory element binding , C85705
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Purification:
- Ammonium Sulfate Precipitated
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- PBS, 0.05% Sodium azide.
- Immunogen:
- Recombinant mouse PREB.
- Uniprot:
- Q9WUQ2
- Synonyms:
- C85705;mammalian guanine nucleotide exchange factor mSec12;prolactin regulatory element-binding protein
- Extra Details:
- Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.
- Shipping Conditions:
- Blue Ice