P Glycoprotein antibody [C219]

Cannot supply to this region.

SKU:: GTX23364
Additional Names:: ATP binding cassette subfamily B member 1 , ABC20 , CD243 , CLCS , GP170 , MDR1 , P-GP , PGY1
Application:: ELISA, Flow Cytometry, IHC, WB, IHC-P, IHC-Fr, IF, ICC, IP
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Bovine, Canine, Fish, Human, Mouse, Rat
Buffer:: PBS, 1% BSA, 0.1% Sodium azide.
Immunogen:: SDS-solubilized plasma membranes of a multidrug resistant Chinese hamster ovary (CHO) cell line and a human cell line.
Clone:: C219
Uniprot:: P08183
Synonyms:: ABC20;ATP-binding cassette sub-family B member 1;ATP-binding cassette, sub-family B (MDR/TAP), member 1;ATP-dependent translocase ABCB1;CD243;CLCS;colchicin sensitivity;doxorubicin resistance;GP170;MDR1;multidrug resistance protein 1;p-170;P-glycoprotein 1;P-GP;PGY1;phospholipid transporter ABCB1
Extra Details:: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Shipping Conditions:: Blue Ice