GTX23270
CFTR antibody [MM13-4]
Cannot supply to this region.
- SKU:
- GTX23270
- Additional Names:
- cystic fibrosis transmembrane conductance regulator , ABC35 , ABCC7 , CF , CFTR/MRP , MRP7 , TNR-CFTR , dJ760C5.1
- Application:
- IHC-P, IF, ICC
- Concentration:
- 0.2 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS, 0.2% BSA, 0.09% Sodium azide.
- Immunogen:
- The immunogen corresponding to a region within amino acids 1387 and 1480 of human CFTR.
- Clone:
- MM13-4
- Uniprot:
- P13569
- Synonyms:
- ABC35;ABCC7;ATP-binding cassette sub-family C member 7;cAMP-dependent chloride channel;CF;CFTR/MRP;channel conductance-controlling ATPase;cystic fibrosis transmembrane conductance regulating;cystic fibrosis transmembrane conductance regulator;cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7);dJ760C5.1;MRP7;TNR-CFTR
- Extra Details:
- This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]
- Shipping Conditions:
- Blue Ice