GTX22480
Myosin Light Chain 2 (phospho Ser19) antibody
Cannot supply to this region.
- SKU:
- GTX22480
- Additional Names:
- myosin light chain 12A , HEL-S-24 , MLC-2B , MLCB , MRCL3 , MRLC3 , MYL2B
- Application:
- ELISA, WB, IHC-P, IHC-Fr, IF, ICC, IP
- Concentration:
- 1.19 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Human Myosin Light Chain phospho peptide corresponding to a region near the amino terminus of the human smooth/non-muscle form of myosin regulatory light chain conjugated to KLH.
- Uniprot:
- O14950, P19105
- Synonyms:
- epididymis secretory protein Li 24;HEL-S-24;MLC-2;MLC-2A;MLC-2B;MLC-B;MLC20;MLCB;MRCL3;MRLC2;MRLC3;MYL2B;myosin regulatory light chain 12A;myosin regulatory light chain 12B;myosin regulatory light chain 2;Myosin regulatory light chain 2-B, smooth muscle isoform;myosin regulatory light chain 2, nonsarcomeric;myosin regulatory light chain 20 kDa;myosin regulatory light chain 3;myosin regulatory light chain MRLC2;myosin regulatory light chain MRLC3;myosin RLC;myosin, light chain 12A, regulatory, non-sarcomeric;myosin, light chain 12B, regulatory;myosin, light polypeptide, regulatory, non-sarcomeric (20kD);SHUJUN-1
- Extra Details:
- Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains each ~200,000 daltons, and four light chains each ~16,000 - 21,000 daltons. Activation of smooth and cardiac muscle primarily involves pathways that increase calcium levels and myosin phosphorylation, resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. This antibody is specific for the phosphorylated form of myosin light chain. The selected peptide sequence used to generate the polyclonal antibody is located near the amino terminal end of the polypeptide corresponding to the smooth/non-muscle form of myosin regulatory light chain found in cardiac myocytes in addition to smooth and non-muscle cells. This sequence differs from that of the sarcomeric/cardiac form of myosin regulatory light chain that has a different sequence around the phosphorylation site. Human and mouse have almost identical sequences. In human the phosphorylation site is pS19, while in mouse the site maps to pS20.
- Shipping Conditions:
- Blue Ice