GTX22445
APAF1 antibody
Cannot supply to this region.
- SKU:
- GTX22445
- Additional Names:
- apoptotic peptidase activating factor 1 , APAF-1 , CED4
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 0.2% Gelatin, 0.1% Sodium azide.
- Immunogen:
- Peptide mapping to the amino terminus of human Apaf-1.
- Uniprot:
- O14727
- Synonyms:
- APAF-1;apoptotic protease-activating factor 1;CED4
- Extra Details:
- This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice