RPA32 antibody [9H8]

Cannot supply to this region.

SKU:: GTX22175
Additional Names:: replication protein A2 , REPA2 , RP-A p32 , RP-A p34 , RPA32
Application:: WB, IHC-P, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Purified
Storage Conditions:: 2-8[o]C
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 0.09% Sodium azide.
Immunogen:: BALB/C mice were injected with purified human RPA protein.
Clone:: 9H8
Uniprot:: P15927
Synonyms:: REPA2;replication factor A protein 2;replication protein A 32 kDa subunit;replication protein A 34 kDa subunit;RF-A protein 2;RP-A p32;RP-A p34;RPA32
Extra Details:: This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

Shipping Conditions:: Blue Ice