GTX22098
Cyclin T1 antibody
Cannot supply to this region.
- SKU:
- GTX22098
- Additional Names:
- cyclin T1 , CCNT , CYCT1 , HIVE1
- Application:
- ELISA, WB, IHC-P, IP
- Concentration:
- 75 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
- Immunogen:
- Cyclin T1 peptide corresponding to an internal region of the human protein conjugated to KLH.
- Uniprot:
- O60563
- Synonyms:
- CCNT;CDK9-associated C-type protein;cyclin C-related protein;cyclin-T1;CYCT1;HIVE1;human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1;MLLT10/CCNT1 fusion
- Extra Details:
- Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. Tat stimulates human HIV-1 viral transcription elongation. This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb. P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev. Cyclin T1 is an exceptionally large cyclin and is therefore a candidate for interactions with regulatory proteins.
- Shipping Conditions:
- Blue Ice