OPG antibody (Biotin)

Cannot supply to this region.

SKU:: GTX18068
Additional Names:: TNF receptor superfamily member11b , OCIF , OPG , PDB5 , TNFRSF11B , TR1 , Osteoprotegerin , osteoclastogenesis inhibitory factor
Application:: ELISA, WB
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, no preservatives.
Immunogen:: Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hOPG (human OPG).
Uniprot:: O00300
Synonyms:: OCIF;OPG;osteoclastogenesis inhibitory factor;osteoprotegerin;PDB5;TR1;tumor necrosis factor receptor superfamily member 11B;tumor necrosis factor receptor superfamily, member 11b
Extra Details:: Osteoprotegerin (OPG) belongs to the TNF receptor (TNFR) family. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.