RIP2 antibody [Nick-1]

Cannot supply to this region.

SKU:: GTX17328
Additional Names:: receptor interacting serine/threonine kinase 2 , CARD3 , CARDIAK , CCK , GIG30 , RICK , RIP2
Application:: WB
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Purified
Storage Conditions:: 2-8[o]C
Supplier:: Genetex
Host:: Rat
Reactivities:: Human
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: Recombinant fragment, corresponding to N terminal amino acids 1-322 of Human RIP2.
Clone:: Nick-1
Uniprot:: O43353
Synonyms:: CARD-carrying kinase;CARD-containing IL-1 beta ICE-kinase;CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase;CARD-containing interleukin-1 beta-converting enzyme-associated kinase;CARD3;CARDIAK;CCK;GIG30;growth-inhibiting gene 30;receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase;receptor-interacting protein 2;receptor-interacting serine/threonine-protein kinase 2;RICK;RIP-2;RIP-like-interacting CLARP kinase;RIP2;tyrosine-protein kinase RIPK2
Extra Details:: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD containing serine/threonine kinase RIP regulates Fas induced apoptosis. A novel CARD containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP like interacting CLARP kinase, receptor interacting protein 2, and CARD containing ICE associated kinase, respectively. RICK contains an N terminal kinase catalytic domain and a C terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF kB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase 1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced apoptosis and that is involved in the generation of proinflammatory cytokine IL1b. The messenger RNA of RICK is expressed in multiple human tissues.

Shipping Conditions:: Blue Ice