GTX17033-PEP
RAN blocking peptide
Cannot supply to this region.
- SKU:
- GTX17033-PEP
- Additional Names:
- Ran, Member Ras Oncogene Family , Ara24 , Gsp1 , Tc4 , Ran
- Physical State:
- Lyophilized
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- RAN, member RAS oncogene family
- Species:
- Human
- Synonyms:
- androgen receptor-associated protein 24;ARA24;Gsp1;GTP-binding nuclear protein Ran;GTPase Ran;guanosine triphosphatase Ran;member RAS oncogene family;RanGTPase;ras-like protein TC4;ras-related nuclear protein;TC4
- Extra Details:
- RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within
- Shipping Conditions:
- Blue Ice