LDL Receptor antibody [15C8]

Cannot supply to this region.

SKU:: GTX16897
Additional Names:: Low Density Lipoprotein Receptor , Ldlr
Application:: ELISA, Flow Cytometry, WB, IHC-Fr, IF, ICC, IP
Concentration:: 0.1 mg/ml
Physical State:: Liquid
Species Reactivity:: Bovine
Storage Conditions:: 2-8[o]C Do not freeze.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Bovine, Human
Buffer:: 50mM Sodium Phosphate, 0.2% Gelatin, 0.1% Sodium azide.
Immunogen:: A trypic digest of low density lipoprotein receptor from bovine
Clone:: 15C8
Synonyms:: LDL receptor;low-density lipoprotein receptor
Extra Details:: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.