GTX16378
TCL1A antibody
Cannot supply to this region.
- SKU:
- GTX16378
- Additional Names:
- T cell leukemia/lymphoma 1A , TCL1
- Application:
- WB, IF, ICC
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1A (NP_001092195.1).
- Uniprot:
- P56279
- Synonyms:
- oncogene TCL-1;oncogene TCL1;protein p14 TCL1;T cell leukemia/lymphoma 1A;T-cell leukemia/lymphoma protein 1A;T-cell lymphoma-1;TCL1
- Extra Details:
- Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
- Shipping Conditions:
- Blue Ice