MTGR1 antibody

Cannot supply to this region.

SKU:: GTX16137
Additional Names:: CBFA2/RUNX1 translocation partner 2 , EHT , MTGR1 , ZMYND3 , p85
Application:: WB
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Sheep
Reactivities:: Human
Buffer:: PBS, 0.08% Sodium azide.
Immunogen:: Unfortunately, this information is considered to be commercially sensitive
Uniprot:: O43439
Synonyms:: CBFA2/RUNX1 translocation partner 2;core-binding factor, runt domain, alpha subunit 2; translocated to, 2;EHT;ETO homolog on chromosome 20;ETO homologous on chromosome 20;MTG8-like protein;MTG8-related protein 1;MTGR1;myeloid translocation gene-related protein 1;myeloid translocation-related protein 1;p85;protein CBFA2T2;ZMYND3
Extra Details:: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Blue Ice