RIP3 antibody [Rippy-3]

Cannot supply to this region.

SKU:: GTX16090
Additional Names:: receptor interacting serine/threonine kinase 3 , RIP3
Application:: WB
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Purified
Storage Conditions:: 2-8[o]C
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 0.02% Sodium azide.
Immunogen:: RIP3 (monoclonal Rippy-3) antibody was raised against recombinant human RIP3.
Clone:: Rippy-3
Uniprot:: Q9Y572
Synonyms:: receptor interacting protein 3;Receptor-interacting protein 3;receptor-interacting serine/threonine-protein kinase 3;RIP-3;RIP-like protein kinase 3;RIP3
Extra Details:: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.