Presenilin 2 antibody [APS 21]

Cannot supply to this region.

SKU:: GTX15548
Additional Names:: presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2
Application:: ELISA, IHC, WB, IHC-P, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 0.1% BSA, 0.05% Sodium azide.
Immunogen:: Synthetic peptide corresponding to residues C(31) Q E G R Q G P E D G E N T A(45) of human PS2.
Clone:: APS 21
Uniprot:: P49810
Synonyms:: AD3L;AD3LP;AD4;AD5;Alzheimer disease 4;CMD1V;E5-1;presenilin-2;PS-2;PS2;STM-2;STM2
Extra Details:: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Blue Ice