GTX15000
Phospholamban (phospho Ser16) antibody
Cannot supply to this region.
- SKU:
- GTX15000
- Additional Names:
- CMD1P , CMH18 , PLB , PLN , phospholamban , Phospholamban
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Bovine, Human, Rabbit
- Buffer:
- 100mM Tris-Glycine, 150mM NaCl, 30% Glycerol, 0.05% Sodium azide.
- Immunogen:
- Synthetic peptide corresponding to aa14-25, RA[pS]TIEMPQQAR-C of human cardiac phospholamban with a cysteine added at the C-terminal, conjugated to KLH.
- Uniprot:
- P26678
- Synonyms:
- cardiac phospholamban;CMD1P;CMH18;PLB
- Extra Details:
- The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
- Shipping Conditions:
- Blue Ice