CSK antibody [CSK-04]

Cannot supply to this region.

SKU:: GTX14996
Additional Names:: CSK , csrc tyrosine kinase , C-terminal Src kinase
Application:: WB, IF, ICC, IP
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: 2-8[o]C Do not freeze.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: PBS, 15mM Sodium azide.
Immunogen:: Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
Clone:: CSK-04
Uniprot:: P41240
Synonyms:: C-Src kinase;c-src tyrosine kinase;CSK, non-receptor tyrosine kinase;protein-tyrosine kinase CYL;tyrosine-protein kinase CSK
Extra Details:: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]