DNMT3A antibody [64B814.1]

Cannot supply to this region.

SKU:: GTX13887
Additional Names:: DNA methyltransferase 3A , MmuIIIA
Application:: Flow Cytometry, WB, IF, ICC
Concentration:: 0.5 mg/ml
Physical State:: Liquid
Species Reactivity:: Human, Mouse
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: PBS, 0.05% BSA, 0.05% Sodium azide.
Immunogen:: This antibody was raised against bacteria expressed HIS-tag recombinant mouse Dnmt3a.
Clone:: 64B814.1
Uniprot:: O88508
Synonyms:: cysteine methyltransferase DNMT3A;DNA (cytosine-5)-methyltransferase 3A;DNA methyltransferase MmuIIIA;DNA MTase MmuIIIA;MmuIIIA
Extra Details:: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.