RPE65 antibody [401.8B11.3D9]

Cannot supply to this region.

SKU:: GTX13826
Additional Names:: retinoid isomerohydrolase RPE65
Application:: Flow Cytometry, WB, IHC-P, IHC-Fr, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Bovine
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Bovine, Canine, Human, Mouse, Porcine, Rat
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: Bovine RPE65 microsomal membrane proteins. [UniProt# Q28175]
Clone:: 401.8B11.3D9
Uniprot:: Q28175
Synonyms:: all-trans-retinyl-palmitate hydrolase;lutein isomerase;meso-zeaxanthin isomerase;retinal pigment epithelium-specific 65 kDa protein;retinal pigment epithelium-specific protein (65kD);retinal pigment epithelium-specific protein 65kDa;retinoid isomerohydrolase;retinol isomerase;RPE65, retinoid isomerohydrolase
Extra Details:: Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.

Shipping Conditions:: Blue Ice