Bacillus anthracis Lethal Factor antibody

Cannot supply to this region.

SKU:: GTX13807
Application:: WB
Physical State:: Liquid
Species Reactivity:: Bacteria
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Bacteria
Buffer:: Serum diluted with PBS, 0.2% Gelatin, 0.05% Sodium azide.
Immunogen:: The antibody was developed by immunizing rabbits with synthetic peptides corresponding to amino acids 779-792 of the Anthrax LF protein (approx. 90 kD).
Extra Details:: Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxicity to occur. It begins with the binding of PA to its cell-surface receptor, ATR (Anthrax Toxin Receptor), at which point PA is cleaved and the resulting 63 kD carboxyl-terminal fragment binds to LF and EF. LF is a protease that is known to cleave members of the mitogen-activated protein kinase kinase (MAPKK) family.