GTX13731
SETD7 antibody
Cannot supply to this region.
- SKU:
- GTX13731
- Additional Names:
- SET domain containing 7, histone lysine methyltransferase , KMT7 , SET7 , SET7/9 , SET9
- Application:
- ChIP, WB, IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Unpurified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Serum, 0.05% Sodium azide.
- Immunogen:
- Two synthethic peptides corresponding to amino acids 131-145 (GEVNEDGEMTGEKIA) and 336-352 (GYDHSPPGKSGPEAPEW) of human SETD7 were used as immunogen for this antibody.
- Uniprot:
- Q8WTS6
- Synonyms:
- H3-K4-HMTase SETD7;histone H3-K4 methyltransferase SETD7;histone H3-lysine 4-specific methyltransferase;histone-lysine N-methyltransferase SETD7;KMT7;lysine N-methyltransferase 7;SET domain containing 7, lysine methyltransferase;SET domain containing lysine methyltransferase 7;SET domain-containing protein 7;SET7;SET7/9;SET9
- Extra Details:
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
- Shipping Conditions:
- Blue Ice